5-Amino-1MQ 5mg

A small molecule that blocks NNMT, an enzyme abundant in fat tissue that quietly consumes two things cells need: nicotinamide (a building block of NAD+) and the methyl donor SAM. Inhibiting it leaves more of both available, nudging fat cells away from storage and toward burning energy. In diet-induced obese mice it reduced fat mass and improved metabolic markers without changing how much the animals ate, and separate work has looked at its ability to restore function in aged muscle stem cells. It is studied for fat metabolism, weight regulation and cellular NAD+ support. Unlike most of this list it is not a peptide but a conventional small molecule.